570 Targeting JAK/STAT and Wnt/b-catenin pathways and 5a-reductase activity to develop an effective anti-hair loss product
نویسندگان
چکیده
Androgenetic alopecia (AGA) is a multi-cause pathology resulting in hair cycle deregulation and production of short, fine hair. New insights into follicle biology understanding AGA have brought new strategies to treat it. The aim this study was demonstrate the interest using ingredients targeting well-known innovative biological targets develop an effective anti-hair loss product. active were evaluated on their ability regulate cycle. Activation Wnt/b-catenin pathway dermal papilla cells (HFDPC) assessed reporter gene assay strategy. Inhibition interleukine-6-induced JAK/STAT activation outer root sheath keratinocytes (ORSK) by measuring STAT3 phosphorylation. Conversion testosterone (T) DHT enzyme 5a-reductase (5aRed) HFDPC analysing T metabolism radiolabelled T. A lotion containing these tested 60 subjects for 3 months, 2 applications per week 1 month then application following months. anagen/telogen (A/T) ratio phototrichogram analysis. combination Nasturtium officinale Tropaeolum majus extracts increased 38% HFDPC. Garcinia Mangostana extract significantly reduced ORSK 33%. Glyceryl laurate conversion 42% suggesting that 5aRed activity inhibited. When subjects, number anagen hairs subjects’ scalp A/T ratio, also decreased telogen after months treatment. Hair ever-evolving science newly described pathways such as with well-chosen will provide patients anti-hair-loss solutions matching needs expectations.
منابع مشابه
Analysis of nitrate reductase mRNA expression and nitrate reductase activity in response to nitrogen supply
Nitrate is one of the major sources of nitrogen for the growth of plants. It is taken up by plant roots and transported to the leaves where it is reduced to nitrite in the. The main objective of this research was to investigate stimulatory effects of sodium nitrate, potassium nitrate, ammonia and urea on the production/generation of the nitrate reductase mRNA in Triticum aestivum plants. The pl...
متن کاملthe innovation of a statistical model to estimate dependable rainfall (dr) and develop it for determination and classification of drought and wet years of iran
آب حاصل از بارش منبع تأمین نیازهای بی شمار جانداران به ویژه انسان است و هرگونه کاهش در کم و کیف آن مستقیماً حیات موجودات زنده را تحت تأثیر منفی قرار می دهد. نوسان سال به سال بارش از ویژگی های اساسی و بسیار مهم بارش های سالانه ایران محسوب می شود که آثار زیان بار آن در تمام عرصه های اقتصادی، اجتماعی و حتی سیاسی- امنیتی به نحوی منعکس می شود. چون میزان آب ناشی از بارش یکی از مولفه های اصلی برنامه ...
15 صفحه اولFrequency of Sodium Valproate-Induced Hair Loss and Curly Hair
Sodium valproate has been widely used by man as an antiepileptic drug. Hair loss and curly hair is a rare side effect of sodium valproate. We have conducted a prospective clinical study in the Department of Neurology in Shafa Hospital, Kerman, Iran for ten years (1994-2004). All 211 epileptic patients in our study were given sodium valproate as a single drug treatment. During the course of ther...
متن کاملDetermination of hair loss (alopecia) cause and effective treatment in laboratory rabbits
In number (16 of 22) of infants in the Dutch laboratory rabbit breeding colony, in aged 45-65 days old, hair loss (alopecia) seen at the top of the head and around a week after the hair fall, was created in a state of complete alopecia. For determination of the cause of hair loss, after the observation and palpation the alopecic area, there have not been any swelling, abscesses, tumors. In skin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.09.586